Results
Characteristics of the Patients
A total of 533 patients with GC were recruited from 3 tertiary referral teaching hospitals, including 194 patients from Zhongnan Hospital of Wuhan University, 182 patients from Heji Hospital and 157 patients from Hubei Tumor Hospital. By the time of last follow-up, 278 deaths (52.2%) occurred, including 126 deaths (64.9%) out of 194 enrolled patients from Zhongnan Hospital of Wuhan University, 84 deaths (46.2%) out of 182 enrolled patients from Heji Hospital, and 68 deaths (43.3%) out of 157 enrolled patients from Hubei Tumor Hospital. The median age of cases was 58 years (range 20–85 years), and male-to-female ratio was 2.7 to 1. Detailed information on major demographic and clinico-pathological characteristics was listed in Table 1.
GC-specific OS
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Figure 1.
Kaplan-Meier survival curve of the 533 GC patients in this study.
Mortality Analysis
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Figure 2.
Information on GC-specific deaths in relationship with clinical stages.
Univariate Survival Analysis
In this study, all variables were analyzed by Kaplan-Meier curve and log-rank test. Among these variables, pathological type had no statistically significant impact on GC-specific OS (P = 0.212), but statistically significant factors were hospital (P = 0.008), age (P < 0.001), gender (P = 0.019), cancer site (P = 0.004), surgery type (P < 0.001), resection type (P < 0.001), other organ resection (P < 0.001), HIPEC (P < 0.001), LN status (P < 0.001), tumor invasion (P < 0.001), distant metastases (P < 0.001), TNM stage (P < 0.001), postoperative SAE (P < 0.001), systemic chemotherapy (P = 0.001), and IP chemotherapy (P = 0.003) (Table 1).
Multivariate Survival Analysis
After univariate survival analysis, the above significant factors were further subjected to multivariate analysis using Cox proportional hazard model and forward regression procedure. The following variables were identified as independent factors for prognosis: tumor invasion (P < 0.001), LN status (P < 0.001), distant metastases (P < 0.001), resection type (P = 0.015), HIPEC (P = 0.049), postoperative SAE (P < 0.001) and systemic chemotherapy (P < 0.001) (Table 2).