Conclusions
Beneficial treatment effects were demonstrated across key outcomes for two included interventions. In indirect comparison nintedanib was associated with significantly better outcome on slowing the decline in FVC than pirfenidone and this finding was robust in sensitivity analyses. Mortality rates showed trends in favour of pirfenidone but these were not statistically significant. Our findings can be used to help inform treatment decisions for this population of patients who following the recent regulator's approvals will benefit from greater access to these therapies.