We all use different drugs for different purposes, the medicinal drugs are crucial for treatment of illnesses; they save lives. There are different types and forms of drugs available in the market. Recently, the liquid filled capsules are fast replacing the traditional capsules and they are increasingly accepted by the pharmaceutical companies from around the world. There are different aspects of liquid capsules manufacturing processes, which are discussed below:
High Potency Products
When it comes to using the high potency products in the drugs, liquid capsules is becoming more and more popular as the best alternative technique than the traditional capsule manufacturing process. From the technical perspective the manufacturing process of capsules with liquid filling is easy and risk free as it eliminates the risk of cross contamination of the various compounds that constitutes the basic ingredients of the drug.
Additionally, these capsules reduce the expenses in using the various engineering control systems for maintaining their stability as well as assure uniformity.
Abuse resistant formulations
In recent times, the pharmaceutical companies from around the world and even the drug regulating authorities like FDA are engaged in researching and development of abuse resistant formulations. The Food and Drugs Authority has asked the pharmacy companies to initiate Risk Evaluation and Mitigation Strategies (REMS) in their manufacturing units to deal with the potential hazards of drug abuse. The main focus area of abuse resistant formulations is in the product of pain management products as well as other drugs such as methylphenidate.
The pharmacy companies nowadays use different strategies such as creating inactive drugs and include sequestered antagonist molecules that produce side effects. With research capsules that have liquid or semi solid filling have known to be more resilient to crushing than the conventional powder capsules. This provides a better basis for developing abuse resistant formulations.
Excipients
Today, the drug manufacturing companies that produce liquid capsules use a wide range of non aqueous excipients. Also, the pharmaceutical companies are also involved in various researches to understand how these materials behave and how they increase the efficiency of the drugs.
Capsule Shells
One of the most common and popular materials used for making capsules is the Gelatin. It is also used for making the liquid filled capsules. However, the recent research suggests that HPMC shells are a better alternative material to gelatine as it helps in getting rid of the compatibility issues with the cross linking of the ingredients.
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