Could ADHD Drug Find New Role in Menopause?
Small study suggests Vyvanse might help with concentration, thought organization
FRIDAY, June 12, 2015 (HealthDay News) -- A drug marketed for attention deficit hyperactivity disorder might improve memory and concentration problems associated with menopause, a new, small study suggests.
Vyvanse (lisdexamfetamine), a stimulant, is usually prescribed to children and adults with ADHD. But researchers found it also may help to improve menopausal women's "executive function" -- brain activities such as memory, reasoning, multitasking, planning and problem-solving.
"We always hear about hot flashes, irregular periods and insomnia classically linked to menopause, but there are other symptoms equally annoying but less talked about," said Dr. Sheryl Ross, an obstetrician-gynecologist at Providence Saint John's Health Center in Santa Monica, Calif., who was not involved in the study. "Cognitive changes happen in the majority of women going through menopause, and memory loss, poor concentration, a short attention span and other cognitive changes can be disruptive and frustrating."
The study was funded by Shire, the drug's maker, and the U.S. National Institutes of Health. The findings were published online June 11 in the journal Psychopharmacology.
The study authors randomly gave 32 women 40 to 60 milligrams of Vyvanse or a placebo daily for four weeks. All were between ages 45 and 60, were either going through or just finishing menopause, and had complained of difficulties with executive function.
None had a history of ADHD, but all scored high enough on an assessment of symptoms to show they were experiencing executive function difficulties at the time of the study. They also underwent several tests related to memory and attention.
After four weeks, the women had a two-week break before the groups switched. Women who got a placebo the first time now received the real medication and vice versa for another four weeks.
The researchers found that the women had better scores on their symptoms assessments while taking the medication. They also scored better on one of the three memory and concentration tests while taking Vyvanse.
Another women's-health expert stressed the need for more studies and more treatment options for menopausal women.
"We need more research before changing our clinical practice, but it is encouraging that we are looking at other treatments for a variety of cognitive, mood and physical symptoms that are present during perimenopause and menopause for women," said Dr. Nicole Cirino, director of women's mental health and wellness at Oregon Health & Science University. "It's especially exciting to see this research for women who cannot tolerate hormone replacement therapy," added Cirino, who was not involved in the study.