Health & Medical Menopause health

Bladder Trabeculation, Pelvic Organ Prolapse in Postmenopause

Bladder Trabeculation, Pelvic Organ Prolapse in Postmenopause

Results


From the medical records, we identified 308 patients who met the inclusion criteria; 169 (54.9%) had BT and 139 (45.1%) did not have BT. Table 1 shows the patients' mean age, parity, body mass index, duration of prolapse, menopause status, diabetes, previous hysterectomy, and stage of prolapse. Except for mean age, there were no statistically significant differences between the two groups. The mean age was higher in women with BT than in those without it (P < 0.001).

The clinical manifestations of patients are shown in Table 2 . The prevalences of urinary urgency, urge incontinence, voiding difficulty, and backache were significantly greater in patients with BT than in those without it. Urodynamic data are shown in Table 3 and reflect no significant differences between the two groups. However, the prevalences of detrusor overactivity and PVR greater than 100 mL were significantly increased in the group with BT (P = 0.004 and P = 0.001, respectively). Patients with BT had a higher prevalence of BOO compared with those without it (P = 0.095). After running logistic regression analysis on all variables, we discovered that detrusor overactivity was the only variable associated with BT (odds ratio, 4.04; 95% CI, 1.48-10.90; P = 0.006).

Severity of BT was classified into five grades: grade 0, 45.1% (n = 139); grade 1, 33.1% (n = 102); grade 2, 11.4% (n = 35); grade 3, 7.1% (n = 22); grade 4 BT, 3.2% (n = 10). To investigate the relationship between clinical manifestations, urodynamic findings, and BT grade, we divided all patients into two groups according to the severity of BT: group 1 (n = 32) included grades 3 and 4 with severe BT, and group 2 (n = 276) included grades 0, 1, and 2 with no BT to moderate BT. There were no statistically significant differences in demographic data between groups 1 and 2 ( Table 4 ). As revealed in Table 5 , the prevalence of urge incontinence was significantly greater in group 1 than in group 2 (P < 0.001).

Table 6 shows that group 1 had significantly higher prevalences of detrusor overactivity (P < 0.001), BOO (P = 0.001), and PVR greater than 100 mL (P = 0.021), and lower maximal cystometric capacity (P = 0.030) than did group 2. On logistic regression analyses on all variables, detrusor overactivity was still the only significant factor for BT (odds ratio, 5.87; 95% CI, 2.27-13.89; P < 0.001).

When we evaluated demonstrable prolapse within a specific vaginal compartment, stages 3 and 4 predominated in the anterior and apical compartments ( Table 7 ). A significant association between severity of trabeculation and stage of anterior vaginal compartment prolapse was discovered: patients with more severe BT had a significantly higher prevalence of advanced stages of anterior vaginal compartment prolapse than did patients with no BT to moderate BT (P = 0.028).

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