The investigators in a new trial tested whether all aspects of early goal-directed therapy (EGDT) are necessary in patients with severe sepsis and septic shock.
The objective of the study was was to demonstrate that there is no clear-cut distinction between treatments administered to relieve pain and suffering and those intended to shorten the dying process.
Paracentesis with parameter-guided fluid substitution and maintenance of central blood volume may improve renal function in the treatment of patients with hepatorenal failure.
This study, performed as an addendum to the placebo-controlled ADDRESS study, reports risk of death and evidence of harm at 1 year associated with drotrecogin alfa (activated).
Reduction in plasma melatonin levels and loss of circadian rhythm observed in critically ill patients receiving mechanical ventilation may contribute to this irregular sleep-wake pattern.
Finally ventilator associated events have standardized definitions and data collection methods. Will standardization positively impact patient care or add to the burden?