Publication of a trial demonstrating large mortality reductions using small tidal volume was associated with significant reductions in tidal volume delivered to patients with ALI/ARDS.
Fever, defined as body temperature >37.9°C, is common in critically ill neurologic and neurosurgical patients, especially those with a prolonged length of stay in the neurologic intensive care unit (NICU) or with intracranial disease.
Rescue hyperinsulinemic euglycemia therapy has resulted in improved hemodynamic parameters and increased metabolic efficiency in patients with a low-output, myocardial shock state.
Guidelines recommend initial empirical treatment with two antibiotics instead of one -- in patients with community-acquired pneumonia requiring ICU admission. Are two really better than one?
Despite the major investment of time, effort, and money to produce more than 1800 clinical practice guidelines, there is little evidence that clinical care has improved based on their publication.